Wake Forest School of Medicine directs nearly 1,900 students and fellows, including physicians, basic scientists, and allied clinical professionals. The School wanted to create a space for the next generation of physician-leaders by offering students an advanced environment in which to learn. Formerly known as Building 60 North, part of the abandoned R.J. Reynolds Tobacco manufacturing plant, Wake Forest’s new School of Medicine adds to the historic rehabilitation and urban revitalization of the north district of the Wake Forest Innovation Quarter. As the third phase in the historic restoration of the former factory, the 168,000 SF School of Medicine builds on innovation and community themes by expanding research departments, technology spin-offs, and other companies interested in collaborative research activities. The building combines numerous sustainable strategies with the highly technical aspects of a medical facility. Today, the building houses over 400 research faculty, graduate students, new start-ups, and visitors who will attend various symposia in the new three-story skylit atrium.